Contenido
Part I: Molecular Biology of Cancer
1. The Cancer Genome NEW!
2. Mechanisms of Genomic Instability
3. Epigenetics of Cancer NEW!
4. Telomeres, Telomerase, and Cancer
5. Cell Signaling, Growth Factors and their Receptors
6. Cell Cycle
7. Mechanisms of Cell Death
8. Cancer Metabolism NEW!
9. Angiogenesis
10. Invasion and Metastasis
11. Cancer Stem Cells
12. Biology of Personalized Cancer Medicine NEW!
Part II: Etiology and Epidemiology of Cancer
Section 1: Etiology of Cancer
13. Tobacco
14. Cancer Susceptibility Syndromes
15. DNA Viruses
16. RNA Viruses
17. Inflammation
18. Chemical Factors
19. Physical Factors
20. Dietary Factors
21. Obesity and Physical Activity
Section 2: Epidemiology of Cancer
22. Epidemiologic Methods
23. Global Cancer Incidence and Mortality
24. Changes in Cancer Mortality
Part III: Principles of Cancer Treatment
25. Surgical Oncology: General Issues
26. Surgical Oncology: Laparoscopic Surgery
27. Radiation Oncology
28. Medical Oncology
29. Assessment of Clinical Response NEW!
30. Cancer Immunotherapy
31. Health Services Research and Economics of Cancer Care
Part IV: Pharmacology of Cancer Therapeutics
Section 1: Chemotherapy Agents
32. Pharmocokinetics and Pharmacodynamics
33. Pharmacogenomics
34. Alkylating Agents
35. Platinum Analogs
36. Antimetabolites
37. Topoisomerase Interactive Agents
38. Antimicrotubule Agents
39. Targeted Therapy with Small Molecule Kinase
Inhibitors NEW!
40. Histone Deacetylase Inhibitors and Demethylating
Agents
41. Proteosome Inhibitors
42. Poly (ADP-ribose) Polymerase Inhibitors NEW!
43. Miscellaneous Chemotherapeutic Agents
Section 2: Biotherapeutics
44. Interferons
45. Interleukin Therapy
46. Antisense Agents
47. Antiangiogenesis Agents
48. Monoclonal Antibodies
49. Endocrine Manipulation
Part V: Cancer Prevention
50. Preventive Cancer Vaccines
51. Tobacco Dependence and Its Treatment
52. Role of Surgery in Cancer Prevention
53. Principles of Cancer Chemoprevention
54. Retinoids, Carotinoids, and other Micronutrients
55. Drugs Used in Chemoprevention
Part VI: Cancer Screening
56. Principles of Cancer Screening
57. Early Detection Using Proteomics NEW!
58. Screening for Gastrointestinal Cancers
59. Screening for Gynecologic Cancers
60. Screening for Breast Cancer
61. Screening for Prostate Cancer NEW!
62. Screening for Lung Cancer
63. Genetic Counseling
Part VII: Specialized Techniques in Cancer Management
64. Vascular Access and Specialized Technique in Drug Delivery
65. Interventional Radiology
66. Functional Imaging
67. Molecular Imaging
68. Photodynamic Therapy
69. Biomarkers
Part VIII: Practice of Oncology
70. Design and Analysis of Clinical Trials
Section 1. Cancer of the Head and Neck
71. Molecular Biology of Head and Neck Cancers
72. Treatment of Head and Neck Cancer
73. Rehabilitation after Treatment of Head and Neck
Section 2. Cancer of the Thoracic Cavity
74. Molecular Biology of Lung Cancer
75. Non-small Cell Lung Cancer
76. Small Cell and Neuroendocrine Tumors of the Lung
77. Neoplasms of the Mediastinum
Section 3: Cancers of the Gastrointestinal Tract
78. Molecular Biology of the Esophagus and Stomach
79. Cancer of the Esophagus
80. Cancer of the Stomach
81. Molecular Biology of Pancreas Cancer
82. Cancer of the Pancreas
83. Molecular Biology of Liver Cancer
84. Cancer of the Liver
85. Cancer of the Biliary Tree
86. Cancer of the Small Intestine
87. Gastrointestinal Stromal Tumors
88. Molecular Biology of Colorectal Cancer
89. Cancer of the Colon
90. Cancer of the Rectum
91. Cancer of the Anal Region
Section 4. Cancers of the Genitourinary System
92. Molecular Biology of Kidney Cancer
93. Cancer of the Kidney
94. Molecular Biology of the Bladder
95. Cancer of the Bladder, Ureter and Renal Pelvis
96. Molecular Biology of Prostate Cancer
97. Cancer of the Prostate
98. Cancer of the Urethra and Penis
99. Cancer of the Testis
Section 5. Gynecologic Cancers
100. Molecular Biology of Gynecologic Cancers
101. Cancer of the Cervix, Vagina and Vulva
102. Cancer of the Uterine Body
103. Gestational Trophoblastic Diseases
104. Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma
Section 6. Cancer of the Breast
105. Molecular Biology of Breast Cancer
106. Malignant Tumors of the Breast
Section 7. Cancer of the Endocrine System
107. Molecular Biology of Endocrine Tumors
108. Thyroid Tumors
109. Parathyroid Tumors
110. Adrenal Tumors
111. Pancreatic Endocrine Tumors
112. Neuroendocrine (Carcinoid) Tumors and the
Carcinoid Syndrome
113. Multiple Endocrine Neoplasias
Section 8. Sarcomas of Soft Tissue and Bone
114. Molecular Biology of Sarcomas NEW!
115. Soft Tissue Sarcoma
116. Sarcomas of Bone
Section 9. Cancers of the Skin
117. Cancer of the Skin
118. Molecular Biology of Cutaneous Melanoma
119. Cutaneous Melanoma
Section 10. Neoplasms of the Central Nervous System
120. Molecular Biology of Central Nervous System Tumors
121. Neoplasms of the Central Nervous System
Section 11. Cancers of Childhood
122. Molecular Biology of Childhood Cancers
123. Solid Tumors of Childhood
124. Leukemias and Lymphomas of Childhood
Section 12. Lymphomas in Adults
125. Molecular Biology of Lymphomas NEW!
126. Hodgkin-s Lymphoma
127. Non-Hodgkin-s Lymphomas
128. Cutaneous Lymphomas
129. Primary Central Nervous System Lymphoma
Section 13. Leukemias and Plasma Cell Tumors
130. Molecular Biology of Acute Leukemias
131. Management of Acute Leukemias
132. Molecular Biology of Chronic Leukemias
133. Chronic Myelogenous Leukemia
134. Chronic Lymphocytic Leukemias
135. Myelodysplastic Syndromes
136. Plasma Cell Neoplasms
Section 14. Other Cancers
137. Cancer of Unknown Primary Site
138. Benign and Malignant Mesothelioma
139. Peritoneal Surface Malignancy
140. Intraocular Melanoma
Section 15. Immunosuppression Related Malignancies
141. AIDS-Related Malignances
142. Transplantation-Related Malignancies
Section 16. Oncologic Emergencies
143. Superior Vena Cava Syndrome
144. Increased Intracranial Pressure
145. Spinal Cord Compression
146. Metabolic Emergencies
Section 17. Treatment of Metastatic Cancer
147. Metastatic Cancer to the Brain
148. Metastatic Cancer to the Lung
149. Metastatic Cancer to the Liver
150. Metastatic Cancer to the Bone
151. Malignant Pleural and Pericardial Effusions
152. Malignant Ascites
153. Paraneoplastic Syndromes
Section 18. Stem Cell Transplantation
154. Autologous Stem Cell Transplantation
155. Allogeneic Stem Cell Transplantation
Section 19. Management of Adverse Effects of Treatment
156. Infections in the Cancer Patient
157. Leukopenia and Thrombocytopenia
158. Cancer Associated Thrombosis
159. Nausea and Vomiting
160. Diarrhea and Constipation
161. Oral Complications
162. Pulmonary Toxicity
163. Cardiac Toxicity
164. Hair Loss
165. Gonadal Dysfunction
166. Fatigue
167. Second Cancers
168. Neurocognitive Effects
169. Cancer Survivorship
Section 20. Supportive Care and Quality of Life
170. Management of Cancer Pain
171. Nutritional Support
172. Sexual Problems
173. Psychological Issues
174. Communicating News to the Cancer Patient
175. Specialized Care of the Terminally Ill
176. Community Resources
177. Rehabilitation of the Cancer Patient
Section 21. Societal Issues in Oncology
178. Regulatory Issues
179. Health Disparities in Cancer
180. Cancer on the Internet
Section 22. Complementary, Alternative,and Integrative Therapies
181. Complementary, Alternative, and Integrative
Author Bio
Vincent T DeVita MD
Theodore S Lawrence MD, PhD
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI
Steven A Rosenberg MD, PhD
Chief of Surgery, National Cancer Institute, National Institutes of Health, Professor of Surgery, Uniformed Services University of the Health Sciences School of Medicine, Bethesda, MD, Professor of Surgery, George Washington University School of Medicine, Washington, DC
Ronald A DePinho MD
Harvard Medical School, Boston, MA
Robert A Weinberg PhD
Massachusetts Institute of Technology, Cambridge, MA